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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

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Related Experiment Video

Updated: Jun 2, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Acral lentiginous melanoma.

Melissa Peck Piliang1

  • 1Department of Dermatology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA. pilianm@ccf.org

Clinics in Laboratory Medicine
|May 10, 2011
PubMed
Summary

Acral lentiginous melanoma (ALM) is a rare skin cancer affecting the hands and feet. Histology shows single melanocytes at the junction, requiring differentiation from benign nevi.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Acral lentiginous melanoma (ALM) is an uncommon but aggressive skin malignancy.
  • It affects the feet and hands, presenting as dark, irregular lesions.
  • ALM has a poorer prognosis compared to other melanoma types.

Purpose of the Study:

  • To describe the clinical and histological characteristics of acral lentiginous melanoma.
  • To differentiate ALM from benign acral lentiginous nevi.

Main Methods:

  • Histopathological examination of skin lesions.
  • Analysis of clinical presentation and patient demographics.

Main Results:

  • ALM presents as asymmetric, poorly circumscribed proliferation of single melanocytes at the dermoepidermal junction.

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Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

Related Experiment Videos

Last Updated: Jun 2, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
08:18

Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma

Published on: September 8, 2021

  • Single melanocytes are predominant over nests in ALM histology.
  • Distinguishing ALM from benign nevi with site-related atypia is crucial.

    • Conclusions:

    • Acral lentiginous melanoma requires careful histological evaluation for accurate diagnosis.
    • Understanding the specific histological features aids in differentiating malignant from benign lesions.