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Thrombotic Risks in Red Blood Cell Transfusions.

Timur Dubovoy1, Milo Engoren1

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PubMed
Summary
This summary is machine-generated.

Transfused red blood cells can cause bleeding or clotting due to storage-induced damage. This review examines how these cellular changes impact hemostasis and thrombosis after transfusion.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Hemostasis and Thrombosis

Background:

  • Red blood cells are crucial for hemostasis and thrombosis.
  • Cellular properties like shape, aggregation, and signaling influence blood flow and coagulation.
  • Storage lesion damages transfused red blood cells, altering their function.

Purpose of the Study:

  • To review the impact of transfused red blood cells on hemostasis and thrombosis.
  • To explore how storage lesion affects red blood cell function post-transfusion.
  • To investigate the potential for both increased hemorrhage and thrombosis.

Main Methods:

  • Literature review of studies on red blood cell function and transfusion.
  • Analysis of factors affecting red blood cell properties during storage.
  • Examination of clinical outcomes related to red blood cell transfusion.

Main Results:

  • Red blood cells influence coagulation through mechanical properties, aggregation, and molecular signaling.
  • Storage lesion alters red blood cell shape, function, and communication.
  • Transfused red blood cells may contribute to both bleeding and clotting complications.

Conclusions:

  • Storage-induced changes in transfused red blood cells can paradoxically increase risks of hemorrhage and thrombosis.
  • Understanding these alterations is vital for optimizing transfusion strategies.
  • Further research is needed to mitigate adverse effects of stored red blood cells.