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Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
Published on: June 24, 2025
Gene Therapy Strategies for Alzheimer's Disease: An Overview
Sandro Alves1, Romain Fol1, Nathalie Cartier1
1INSERM U1169/MIRCen CEA 92265 Fontenay aux Roses and Université Paris-Sud, Université Paris-Saclay , Orsay, France .
Abstract:
Key neuropathological hallmarks of Alzheimer's disease (AD) are extracellular amyloid plaques and intracellular accumulation of hyperphosphorylated Tau protein. The mechanisms underlying these neuropathological changes remain unclear. So far, research on AD therapy has had limited success in terms of symptomatic treatments although it has also had several failures for disease-modifying drugs. Gene transfer strategies to the brain have contributed to evaluate in animal models many interesting tracks, some of which should deserve clinical applications in AD patients in the future.
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