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Updated: Mar 26, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
Published on: February 3, 2016
IgG4-related Disorders of the Gastrointestinal Tract
Madelyn Lew1, Vikram Deshpande1
1Department of Pathology, Massachusetts General Hospital, 55 Fruit street, Boston, MA 02114, USA.
Abstract:
IgG4-related disease, a newly established multisystemic disease can affect virtually every organ. Histologically, it is characterized by the presence of a dense lymphoplasmacytic infiltrate, storiform-type fibrosis, and obliterative phlebitis. The disease shows elevated serum and tissue IgG4. The pancreas and hepatobiliary tract are involved far more commonly than the tubular gut. This review summarizes the clinical and pathologic features of the gastrointestinal manifestations of IgG4-related disease and discusses the wide spectrum of diseases that this entity may mimic.
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