Diagnosis in Pediatric Transplant Biopsies

Infant recipients have better survival after solid organ transplantation than older children and adults possibly due to immune tolerance. Over the past two decades, postsurgical complications have markedly decreased, and multidrug immunosuppressive regimens have become effective in preventing and treating rejection. Immunocompromised for life, these patients are susceptible to both the usual bacterial as well as opportunistic infections that often involve the lung. Post-transplant lymphoproliferative disease seems to be decreasing even further in frequency. This article focuses on the findings seen on biopsy, usually of the transplanted organ, and also of other sites affected by post-transplant complications.