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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Video

Updated: Mar 26, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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Herpesvirus-Associated B-cell Proliferations.

Laurence de Leval1

  • 1Institute of Pathology, Centre Hospitalier Universitaire Vaudois, 25 rue du Bugnon, 1011 Lausanne, Switzerland.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary

This review covers Epstein-Barr virus and Kaposi sarcoma herpesvirus (KSHV/HHV-8)-associated B-cell lymphoid proliferations. It focuses on their pathology, clinical presentation, diagnosis, and differential diagnosis challenges for pathologists.

Keywords:
BurkittCastleman diseaseEpstein-Barr virusHHV-8HIVHodgkinImmunodeficiencyKaposi sarcoma herpesvirusPlasmablastic

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Area of Science:

  • Pathology
  • Virology
  • Hematology

Background:

  • Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV/HHV-8) are linked to various B-cell lymphoid proliferations.
  • These conditions present unique diagnostic challenges in clinical practice.

Purpose of the Study:

  • To review the spectrum of EBV and KSHV/HHV-8-associated B-cell lymphoid proliferations.
  • To highlight their pathologic features, clinical presentation, diagnostic criteria, and pathogenesis.
  • To emphasize differential diagnosis issues faced by pathologists.

Main Methods:

  • Literature review of EBV and KSHV/HHV-8-associated B-cell lymphoid proliferations.
  • Analysis of pathologic features, clinical presentation, and diagnostic criteria.
  • Discussion of pathogenetic aspects and differential diagnosis.

Main Results:

  • Comprehensive overview of EBV and KSHV/HHV-8-associated B-cell lymphoid proliferations.
  • Detailed description of their distinct pathologic and clinical characteristics.
  • Identification of key diagnostic criteria and challenges.

Conclusions:

  • Accurate identification of these lymphoid proliferations requires understanding their spectrum and features.
  • Pathologists must be aware of differential diagnosis challenges for correct interpretation.
  • Further research into pathogenesis may improve diagnostic strategies.