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Isolation of Neonatal Extrahepatic Cholangiocytes
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Neonatal herpes simplex virus presenting with isolated liver failure.

Marwan Al Aswad1, Manika Suryadevara1

  • 1SUNY Upstate Medical University, Department of Pediatrics, 750 East Adams Street, Syracuse, NY 13210, United States.

Idcases
|February 4, 2016
PubMed
Summary

Neonatal herpes simplex virus (HSV) infection can be severe, often affecting multiple organs. This case highlights a rare instance of isolated liver failure in an infant caused by HSV-2, emphasizing the need for vigilance.

Keywords:
Disseminated diseaseHepatitisHerpes simplex virus

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Area of Science:

  • Neonatal Medicine
  • Virology
  • Pediatric Infectious Diseases

Background:

  • Neonatal herpes simplex virus (HSV) infection is a serious condition with high mortality.
  • Disseminated neonatal HSV typically involves multiple organs.
  • Early diagnosis and treatment are crucial for improving outcomes.

Purpose of the Study:

  • To report a unique case of neonatal herpes simplex virus type 2 (HSV-2) infection.
  • To describe an infant presenting with isolated hepatic failure without disseminated disease.
  • To underscore the varied clinical presentations of neonatal HSV.

Main Methods:

  • Case report of a 3-week-old infant.
  • Clinical presentation and diagnostic evaluation.
  • Review of relevant literature on neonatal HSV presentations.

Main Results:

  • The infant presented with compensated hepatic failure as the sole manifestation of HSV-2 infection.
  • The infant appeared well despite the isolated organ involvement.
  • This presentation is atypical for disseminated neonatal HSV.

Conclusions:

  • Isolated hepatic failure can be a presentation of neonatal HSV-2 infection.
  • This case expands the spectrum of clinical manifestations of neonatal herpes.
  • Vigilance for atypical presentations is essential in diagnosing neonatal herpes.