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Updated: Mar 26, 2026

A Microfluidic Chip for ICPMS Sample Introduction
Published on: March 5, 2015
HPLC-MS with Glass Chips Featuring Monolithically Integrated Electrospray Emitters of Different Geometries
Carsten Lotter1, Josef J Heiland1, Sebastian Thurmann1
1Institute of Analytical Chemistry, University of Leipzig , Linnéstraße 3, 04103 Leipzig, Germany.
Abstract:
We present and evaluate an approach for coupling liquid chromatography in glass chips with mass spectrometry via fully integrated electrospray emitters. We developed an instrumental platform which allows a robust and reproducible operation of high performance chip chromatography coupled to mass spectrometry. A comparison of differently shaped emitters, from flat over edged to pulled geometries, revealed that all types performed equally well for typical nano-HPLC flow rates. At very low flow rates below 50 nL·min(-1) very sharp, pulled nanospray emitters turned out to be mandatory for the generation of a stable electrospray.
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