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Related Concept Videos

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
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Graded Potential01:19

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Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
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Related Experiment Video

Updated: Mar 26, 2026

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
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Triplet Spike Time-Dependent Plasticity in a Floating-Gate Synapse.

Roshan Gopalakrishnan, Arindam Basu

    IEEE Transactions on Neural Networks and Learning Systems
    |February 4, 2016
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    This study presents a novel synapse implementation using a floating-gate transistor to demonstrate triplet spike-timing-dependent plasticity (T-STDP). This approach offers a compact, nonvolatile method for advanced neural network learning rules.

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    Area of Science:

    • Neuroscience and Neuromorphic Engineering
    • Integrated Circuit Design for AI

    Background:

    • Synaptic plasticity is crucial for neural network learning, with spike-timing-dependent plasticity (STDP) rules modifying synaptic strength based on spike timing.
    • The commonly used doublet STDP (D-STDP) has limitations in replicating biological experimental results.
    • Triplet STDP (T-STDP), considering spike triplets, has been proposed to better explain biological observations.

    Purpose of the Study:

    • To describe a compact synapse implementation using a single floating-gate (FG) transistor for nonvolatile weight storage.
    • To demonstrate the triplet STDP (T-STDP) learning rule using this FG synapse.
    • To present a mathematical procedure for obtaining control voltages for T-STDP in FG devices.

    Main Methods:

    • Implementation of a synapse using a single floating-gate (FG) transistor for nonvolatile weight storage.
    • Demonstration of the T-STDP learning rule by modulating drain voltages based on spike triplets.
    • Fabrication of an FG synapse in a TSMC 0.35-μm CMOS process and measurement of its performance.
    • Simulation of very large scale integration (VLSI) compatible drain voltage waveform generator circuits.

    Main Results:

    • Successful demonstration of T-STDP learning rule implementation using a compact FG synapse.
    • Measurement results from the fabricated FG synapse support the theoretical framework.
    • Simulation results indicate the feasibility of VLSI implementation for T-STDP waveform generation.

    Conclusions:

    • A compact, nonvolatile FG synapse can effectively implement the T-STDP learning rule.
    • The proposed method provides a viable pathway for advanced, biologically plausible learning in neuromorphic systems.
    • The study validates the T-STDP theory with experimental data and suggests practical VLSI integration strategies.