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Updated: Mar 26, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
[Renal urothelial carcinoma mainly composed of signet-ring cells]
S A Povzun1, E A Guseva2, A M Konstantinova3
1Department of Pathomorphology and Clinical Expertise, I.I. Janelidze Saint Petersburg Research Institute of Emergency Care; Saint Petersburg Bureau of Forensic Medical Examination.
Abstract:
Autopsy study of an 80-year-old man has identified his renal tumor metastasizing to the heart, lung, and liver as urothelial car- cinoma; at the same time some cells in the main tumor and all cells in the metastases had a signet-ring phenotype, but neither mucicarcimine nor alcian blue stained the cell cytoplasm. The paper provides the histological and immunohistochemical pattern of the tumor and emphasizes its exclusive rarity. Attention is drawn to the possibility of signet-ring cell transformation in the cells of different tumors, including nonepithelial ones.
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