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Updated: Mar 26, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.9K
[Cardiovascular Disease In Children With Ckd]
Summary
Children with early-stage chronic kidney disease (CKD) show significant cardiac and vascular geometry changes. These include higher left ventricular mass index and pulse wave velocity, indicating increased cardiovascular risk.
Area of Science:
- Pediatric Nephrology
- Cardiovascular Health in Chronic Illness
- Clinical Assessment of Pediatric CKD
Background:
- Cardiovascular disease (CVD) is a leading cause of death in chronic kidney disease (CKD) patients.
- Early detection of cardiac and vascular changes in pediatric CKD is crucial for risk stratification.
Purpose of the Study:
- To assess cardiac and vascular geometry in children with early-stage CKD (stages 2-4).
- To identify early signs of cardiovascular alterations in pediatric CKD.
Main Methods:
- Echocardiography and pulse wave velocity (PWV) measurements were performed on 27 children with CKD and 30 controls.
- Evaluated parameters included left ventricular mass index (LVMI), interventricular septal thickness, and PWV.
Main Results:
- CKD patients exhibited significantly higher LVMI and PWV compared to controls.
- Left ventricular hypertrophy (LVH) was observed in 12% and concentric remodeling in 36% of pediatric CKD patients.
- PWV correlated significantly with interventricular septal thickness and LVMI.
Conclusions:
- Early stages of CKD in children are associated with significant cardiac and vascular geometric alterations.
- Echocardiography and PWV are valuable tools for assessing cardiovascular risk in pediatric CKD stages 2-4.
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