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Updated: Aug 5, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution
Xiukun Lin1, Ammad Ahmad Farooqi2, Muhammad Zahid Qureshi3
1Department of Pharmacology, Capital Medical University, Beijing, People's Republic of China.
Abstract:
It is becoming characteristically more understandable that within tumor cells, there lies a sub-population of tumor cells with "stem cell" like properties and remarkable ability of self-renewal. Many features of these self-renewing cells are comparable with normal stem cells and are termed as "cancer stem cells". Accumulating experimentally verified data has started to scratch the surface of spatio-temporally dysregulated intracellular signaling cascades in the biology of prostate cancer stem cells. We partition this multicomponent review into how different signaling cascades operate in cancer stem cells and how bioactive ingredients isolated from natural sources may modulate signaling network.

