Related Experiment Videos
D2-dopaminergic blockade does not influence post-exercise ketosis in non-athletes
Y A Vahed1, J H Koeslag, J V Lochner
1Department of Physiology, Medical School, University of Cape Town, Observatory, South Africa.
Summary
D2-dopaminergic blockade with metoclopramide did not affect post-exercise ketosis in humans. Unlike starvation ketosis, the prolactin and D2-dopaminergic systems are not involved in exercise-induced ketosis.
Area of Science:
- Endocrinology
- Exercise Physiology
- Metabolism
Background:
- Metoclopramide inhibits starvation ketosis.
- The role of D2-dopaminergic pathways in post-exercise ketosis is unknown.
Purpose of the Study:
- To investigate the effect of D2-dopaminergic blockade on post-exercise ketosis.
Main Methods:
- Six carbohydrate-starved individuals received metoclopramide after a 9-km walk.
- Nine control subjects completed the walk without metoclopramide.
- Plasma prolactin, 3-hydroxybutyrate, free fatty acid, glucose, insulin, and glucagon were measured.
Main Results:
- Metoclopramide significantly increased plasma prolactin levels.
- Metoclopramide did not alter 3-hydroxybutyrate, free fatty acid, glucose, insulin, or glucagon concentrations.
- Post-exercise ketosis was not influenced by D2-dopaminergic blockade.
Conclusions:
- The D2-dopaminergic system and prolactin do not play a role in post-exercise ketosis.
- Post-exercise ketosis differs mechanistically from starvation ketosis.