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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Overview of the Vascular System01:20

Overview of the Vascular System

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The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
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Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lymphatic System in Cardiovascular Medicine.

Aleksanteri Aspelund1, Marius R Robciuc1, Sinem Karaman1

  • 1From the Wihuri Research Institute (A.A., M.R.R., S.K., K.A.) and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (A.A., M.R.R., K.A.); and Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (T.M.).

Circulation Research
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The lymphatic system is crucial for fluid balance and immunity. Recent studies link lymphatic dysfunction to cardiovascular diseases like obesity and atherosclerosis.

Keywords:
cardiovascular diseasesendothelial cellslymphangiogenesisvascular endothelial growth factor Cvascular endothelial growth factor receptor-3

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Area of Science:

  • Cardiovascular Biology
  • Lymphatic Vascular Biology

Background:

  • The mammalian circulatory system includes cardiovascular and lymphatic networks.
  • The lymphatic system is a unidirectional pathway regulating tissue fluid, lipid absorption, and immune cell transport.
  • Lymphatic malfunction manifests as lymphedema and is increasingly linked to cardiovascular pathologies.

Purpose of the Study:

  • To review recent advances in lymphatic vascular biology.
  • To highlight the role of the lymphatic system in cardiovascular disease pathogenesis.

Main Methods:

  • Literature review of recent research in lymphatic vascular biology.
  • Focus on studies implicating the lymphatic system in cardiovascular diseases.

Main Results:

  • The lymphatic system plays a key role in maintaining tissue fluid homeostasis.
  • Lymphatic system dysfunction is associated with obesity, metabolic disease, dyslipidemia, inflammation, atherosclerosis, hypertension, and myocardial infarction.

Conclusions:

  • The lymphatic system is integral to cardiovascular health.
  • Emerging research underscores the lymphatic system's involvement in a spectrum of cardiovascular diseases.