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Updated: Mar 26, 2026
Super-Resolution Imaging of Bacterial Secreted Proteins Using Genetic Code Expansion
Published on: February 10, 2023
Visualization of Anticancer Salmonella typhimurium Engineered for Remote Control of Therapeutic Proteins
1Laboratory of In Vivo Molecular Imaging, Department of Nuclear Medicine, Chonnam National University Medical School, 5, Hak 1 dong, Dong-gu, Gwangju, 501-746, South Korea.
Abstract:
Tumor-targeting bacteria are studied for their ability to carry therapeutic molecules to tumors or, when designed as imaging probes, to visualize the infection pathway. The present protocol describes a method to achieve remote control of therapeutic gene expression in bacteria which are also engineered to visualize the therapeutic process. This strategy may increase the safety of bacteria used to deliver therapeutic genes to tumors in vivo.
