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Updated: Mar 26, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss
Xiaojiang Lin1, Yaoshu Teng2, Jinshan Lan3
1Department of Otorhinolaryngology Head and Neck Surgery, Kaihua People's Hospital, Quzhou, Zhejiang 324300, P.R. China.
Genetic variations in the grainyhead-like 2 (GRHL2) gene, specifically rs611419 and rs10955255, show a protective effect against sudden sensorineural hearing loss (SSHL). These GRHL2 polymorphisms reduce the risk of developing SSHL in the studied population.
Area of Science:
- Genetics
- Otolaryngology
- Molecular Biology
Background:
- Sudden sensorineural hearing loss (SSHL) is a complex condition with multifactorial causes, including genetic predisposition.
- The grainyhead-like 2 (GRHL2) gene plays a role in epithelial development and has been implicated in various cellular processes.
- Investigating genetic polymorphisms in GRHL2 may reveal associations with SSHL susceptibility.
Purpose of the Study:
- To investigate the association between genetic polymorphisms in the grainyhead-like 2 (GRHL2) gene and the risk of sudden sensorineural hearing loss (SSHL).
- To identify specific GRHL2 variants that confer a protective or risk effect against SSHL.
Main Methods:
- A case-control study was conducted with 190 SSHL patients and 210 healthy controls.
- Genomic DNA was extracted from peripheral blood for genotyping.
- Polymerase chain reaction (PCR)-restriction fragment length polymorphism was employed to analyze GRHL2 genotypes, focusing on single nucleotide polymorphisms (SNPs) rs611419, rs10955255, and rs6989650.
Main Results:
- GRHL2 rs611419 polymorphisms (AT+TT vs. AA) showed a protective effect against SSHL (OR=0.63, P=0.038).
- rs10955255 polymorphisms (AA vs. GG and GA+AA vs. GG) were associated with a reduced risk of SSHL (OR=0.54, P=0.032; OR=0.58, P=0.012, respectively).
- Combined genotypes of rs611419, rs10955255, and rs6989650 were associated with a reduced SSHL risk (P=0.035). In alcohol consumers, 3-8 variant alleles conferred increased resistance (OR=0.40, P=0.004). SNP rs6989650 alone was not significantly associated with SSHL.
Conclusions:
- GRHL2 genetic polymorphisms, specifically rs611419 and rs10955255, play a protective role against sudden sensorineural hearing loss.
- These findings suggest that certain GRHL2 variants can reduce the risk of developing SSHL.
- The study highlights the potential genetic contribution of GRHL2 to SSHL etiology, with possible modulation by environmental factors like alcohol consumption.
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