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Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
Bronchoalveolar lavage chitotriosidase activity as a biomarker of sarcoidosis
Matevž Harlander1, Barbara Salobir, Mirjana Zupančič
1Department of Pulmonary diseases, University Medical Centre Ljubljana. matevz.harlander@gmail.com.
Background:
Chitotriosidase (CTO) was shown to be a good biomarker of sarcoidosis. Increased levels in bronchoalveolar lavage fluid (BALF) were reported and associated with more severe forms of the disease.
Objectives:
The aim of the study was to evaluate the value of CTO in BALF as a routine biomarker of sarcoidosis.
Methods:
The study included 85 patients in 9 control subjects in whom serum and BALF CTO were measured.
Results:
Significantly higher CTO levels were detected in BALF of sarcoidosis patients than in control subjects (p < 0.001). There was good correlation between serum and BALF CTO levels in sarcoidosis patients (Spearman's Rho 0.481, p < 0.001). Serum but not BALF CTO had good correlation with clinical parameters. Only in a group of patients with BALF CTO above upper normal range there was association of BALF CTO with impaired FVC (p = 0.020) and chest radiograph score (0-2 vs. 3-4, p = 0.016).
Conclusions:
In comparison to serum CTO no additional benefit of determining CTO in BAL for routine sarcoidosis workup was shown.
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