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Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2.

Nikolas Hundt1, Walter Steffen2, Salma Pathan-Chhatbar1

  • 1Institute for Biophysical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Scientific Reports
|February 6, 2016
PubMed
Summary

Tropomyosin 4.2 (Tpm4.2) enhances the processive behavior of myosin NM-2A under resisting loads. This finding clarifies Tpm4.2's role in cellular tension and stress fiber formation.

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