Design and optimization of tricyclic gamma-secretase modulators
Jianliang Shi1, Dmitry Zuev1, Li Xu1
1Discovery, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
Bioorganic & Medicinal Chemistry Letters
|February 6, 2016
Abstract:
Beginning with a diaminotriazine screening hit, several series of novel, tricyclic gamma-secretase modulators (GSMs) were designed. The SAR of several related series of GSMs is presented, and the in vivo profile of a lead molecule from the series is described.
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