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Radiation-Induced Breast Angiosarcoma: Case Report and Clinical Approach
Cheryl Brus Peterson1, Solange Beauregard2
1Université de Sherbrooke, Sherbrooke, QC, Canada cbruspeterson@gmail.com.
Journal of Cutaneous Medicine and Surgery
|February 6, 2016
Summary
Radiation-induced angiosarcoma, a rare but aggressive breast cancer complication, requires vigilant long-term surveillance after radiation therapy. Early detection and prompt management are crucial for improving patient survival outcomes.
Area of Science:
- Oncology
- Surgical Pathology
- Radiation Oncology
Background:
- Radiation-induced angiosarcoma (RIAS) is a rare but aggressive malignancy complicating breast-conserving therapy.
- Early detection is critical for improving survival, necessitating a high index of suspicion.
Observation:
- A case of left breast RIAS presented 14 years post-radiation therapy.
- Histopathology confirmed angiosarcoma with positive markers for CD31, CD34, D2-40, and Factor VIII (von Willebrand).
Findings:
- The patient underwent total mastectomy and remains in remission at 20 months post-surgery.
- Review of clinical presentation, diagnostics, and treatment options for RIAS is presented.
Implications:
- Long-term follow-up is essential for patients with a history of breast radiation.
- Prompt investigation of subtle skin changes in the breast post-radiation may facilitate early RIAS diagnosis and management.
