Association between IL-27 2905T/G genotypes and the risk and survival of cervical cancer: a case-control study
Guo-Qing Wang1,2, Wen-Hui Zhao3, Xi-Xia Zhao2
1a Department of Internal Medicine-Oncology , the First Affiliated Hospital of Xi 'an Jiaotong University , Shaanxi , China .
Background:
Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties.
Patients And Methods:
A case-control study was conducted to investigate the possible associations of IL-27 gene polymorphisms with susceptibility to cervical cancer and clinical outcome.
Results:
Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients.
Conclusion:
Our results showed that the IL-27 2905T/G genotypes were associated with decreased the susceptibility and development of cervical cancer in Chinese Han population.
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