Apolipoprotein E Genotypes in Patients with Prostate Cancer
Faruk Yencilek1, Seda Gulec Yilmaz2, Asif Yildirim3
1Department of Urology, Faculty of Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
The E3/E3 genotype is linked to increased prostate cancer risk and higher Gleason scores. Conversely, the E4 allele may reduce prostate cancer risk, suggesting distinct roles for apolipoprotein E variants.
Area of Science:
- Genetics
- Oncology
- Biochemistry
Background:
- Apolipoprotein E (ApoE) influences cell proliferation, immune regulation, and antioxidant activity.
- ApoE plays a role in prostate cancer progression.
Purpose of the Study:
- To investigate the association between Apolipoprotein E (ApoE) genotypes and prostate cancer risk.
- To determine if specific ApoE genotypes correlate with prostate cancer severity, such as Gleason score.
Main Methods:
- Apolipoprotein E (ApoE) genotyping was conducted using real-time polymerase chain reaction (RT-PCR).
- Blood samples were analyzed from 68 prostate cancer patients and 78 healthy controls.
Main Results:
- The E3/E3 genotype was significantly more frequent in prostate cancer patients (OR=3.67, p=0.004) and associated with higher Gleason scores (p=0.017).
- The E4 allele was more common in controls (p=0.006), with the E3/E4 genotype being less frequent in patients (OR=0.89, p=0.007).
- The E2/E3 genotype was linked to lower Gleason scores (p=0.049).
Conclusions:
- The E3/E3 genotype may indicate a higher risk for prostate cancer and elevated Gleason scores.
- The E4 allele might act as a protective factor against prostate cancer development.
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