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Mesenteric Artery Contraction and Relaxation Studies Using Automated Wire Myography
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Taurochenodeoxycholate relaxes rat mesenteric arteries through activating eNOS: Comparing with glycochenodeoxycholate

Chang-Lin Zhen1, Jie Yan1, Yu Zhao1

  • 1Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin 150086, PR China.

European Journal of Pharmacology
|February 7, 2016
PubMed
Summary

Taurochenodeoxycholate (TCDC) relaxes rat mesenteric arteries by activating endothelial nitric oxide synthase (eNOS). This bile acid conjugate shows potential for vasorelaxation in vivo, particularly in liver disease contexts.

Keywords:
GlycochenodeoxycholateTaurochenodeoxycholateTauroursodeoxycholateVasorelaxationeNOS

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