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Topology sorting and characterization of folded polymers using nano-pores
Narges Nikoofard1, Alireza Mashaghi2
1Institute of Nanoscience and Nanotechnology, University of Kashan, Kashan 51167-87317, Iran.
Nanoscale
|February 9, 2016
Summary
This study uses molecular dynamics simulations to show that nanopores can distinguish and sort folded polymers based on their unique circuit topology. This technology can characterize molecules by their folding patterns and contact site positions.
Area of Science:
- Polymer Physics
- Nanotechnology
- Computational Chemistry
Background:
- Understanding polymer folding and translocation is crucial for molecular characterization.
- Nanopore technology offers potential for single-molecule analysis.
Purpose of the Study:
- To investigate the translocation of folded polymers through nanopores.
- To explore the use of nanopores for distinguishing molecules based on their topology and folding states.
Main Methods:
- Molecular dynamics simulations were employed to model polymer translocation.
- Two scenarios were simulated: polymers maintaining their fold and polymers unfolding during passage.
Main Results:
- Nanopore passage dynamics differ for polymers with distinct circuit topologies, enabling selective enrichment.
- Nanopores can identify polymer topology for short chains and discriminate between different folding states.
- Contact site positions along the polymer chain can be determined when unfolding occurs during passage.
Conclusions:
- Nanopore technology is applicable for characterizing and sorting molecules based on their topology.
- This method allows for detailed analysis of polymer folding and intramolecular contacts.
