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Microfluidic magnetic self-assembly at liquid-liquid interfaces.

Steven G Jones1, Niki Abbasi, Byeong-Ui Moon

  • 1Ryerson University, Mechanical and Industrial Engineering, Toronto, Canada. scott.tsai@ryerson.ca.

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|February 9, 2016
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We developed a microfluidic method to control microparticle cluster size at liquid-liquid interfaces using magnetic fields and interfacial tension. This technique enables precise control over microscale self-assembly for applications like cell clustering.

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Area of Science:

  • Microfluidics
  • Materials Science
  • Biotechnology

Background:

  • Microfluidic devices enable precise control over fluid dynamics at the microscale.
  • Self-assembly of microparticles is crucial for various applications, including drug delivery and tissue engineering.
  • Controlling the size and structure of microparticle assemblies at interfaces remains a challenge.

Purpose of the Study:

  • To present a novel microfluidic method for controllable self-assembly of microparticles into clusters.
  • To investigate the influence of magnetic field gradients and interfacial tension on cluster size.
  • To develop a scaling model for predicting cluster size.

Main Methods:

  • Utilized a microfluidic cross-slot device to form an aqueous two-phase liquid-liquid interface.
  • Employed converging flows of dextran and polyethylene glycol solutions.
  • Applied variable magnetic field gradients and adjusted interfacial tension to control self-assembly.
  • Developed a scaling model based on the magnetic Bond number.

Main Results:

  • Microparticle clusters were controllably self-assembled at the liquid-liquid interface.
  • Cluster size increased with higher interfacial tension and decreased magnetic field gradient.
  • An inverse scaling relationship was observed between cluster size and the dimensionless magnetic Bond number.
  • Identified distinct magnetic Bond number regimes affecting fluid coating and encapsulation of clusters.

Conclusions:

  • The microfluidic method offers precise control over microparticle cluster size and assembly.
  • The findings provide a foundation for designing microscale self-assemblies with tailored properties.
  • Potential applications include clustering and coating of cells for immunoisolated transplants.