[Effect of beta blockers on retinal hemodynamics. A double-blind study in healthy probands]

In a randomized double-blind study the effect of topically applied Timolol (Chibro-Timoptol 0.5%) on the retinal circulation was investigated. In order to quantify the retinal hemodynamics 20 healthy volunteers were examined twice using video fluorescein angiography. The arteriovenous passage time (AVP) and the dye bolus velocity (MDV) were quantified using an image-analyzing system. Following administration of Timolol, IOP decreased from 14.5 +/- 1.9 mm Hg to 9.4 +/- 1.7 mm Hg (P less than 0.010). The study also showed that there was a significant reduction in AVP from 1.75 +/- 0.5 s to 1.56 +/- 0.3 s (P less than 0.05) and an increase in MDV following local application of Timolol. No effect on systemic blood pressure or pulse rate was observed. The results indicate that in addition to its pressure-lowering effect, timolol also leads to increased retinal perfusion.