Related Experiment Video
Updated: Mar 26, 2026

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
Protein Stability in Reverse Micelles
Michael Senske1, Austin E Smith2, Gary J Pielak3
1Department of Physical Chemistry II, Ruhr-Universität Bochum, 44780, Bochum, Germany.
Abstract:
The N-terminal SH3 domain of the Drosophila signal transduction protein drk was encapsulated in reverse micelles. Both the temperature of maximum stability and the melting temperature decreased on encapsulation. Dissecting the temperature-dependent stability into enthalpic and entropic contributions reveals a stabilizing enthalpic and a destabilizing entropic contribution. These results do not match the expectations of hard-core excluded volume theory, nor can they be wholly explained by interactions between the head groups in the reverse micelle and the test protein. We suggest that geometric constraints imposed by the reverse micelles need to be considered.
More Related Videos
09:57A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
09:49Sedimentation Equilibrium of a Small Oligomer-forming Membrane Protein: Effect of Histidine Protonation on Pentameric Stability
Published on: April 2, 2015
Related Concept Videos
Micelles
RNA Stability
Microtubule Instability
Detergent Purification of Membrane Proteins
The Colloidal State
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention