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Sandwich-format 3D printed microfluidic mixers: a flexible platform for multi-probe analysis.
Drew P Kise1, Michael J Reddish1, R Brian Dyer1
1Chemistry Department, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA.
Journal of Micromechanics and Microengineering : Structures, Devices, and Systems
|February 9, 2016
Summary
A novel microfluidic mixer platform uses 3D printing for versatile biomolecular applications. Its sandwich design enables multiple spectroscopic probes, enhancing kinetic studies and chemical synthesis monitoring.
Area of Science:
- Materials Science
- Chemical Engineering
- Biotechnology
Background:
- Microfluidic mixers are crucial for biomolecular applications but often lack versatility.
- Current designs can be limited in their ability to integrate multiple analytical techniques.
Purpose of the Study:
- To develop a flexible microfluidic mixer fabrication platform for biomolecular applications.
- To enable the simultaneous use of multiple spectroscopic probes with a single microfluidic device.
Main Methods:
- Fabrication of a sandwich-format microfluidic mixer using a 3D printer for polymer spacers.
- Integration of three different channel designs and three distinct spectroscopic probes (UV, mid-IR).
- Utilizing transparent windows (e.g., CaF2) for broad spectral probe compatibility.
Main Results:
- Demonstrated a versatile microfluidic mixer platform adaptable to various channel designs.
- Successfully integrated multiple spectroscopic probes without device modification.
- Showcased the platform's utility for intricate kinetic schemes and chemical synthesis monitoring.
Conclusions:
- The sandwich-format microfluidic mixer, fabricated using cost-effective 3D printing, enhances flexibility and accessibility.
- This approach expands the applicability of microfluidics for complex analyses requiring multiple detection methods.
