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Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
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Tropheryma whipplei infection and Whipple's disease

Thomas Marth1, Verena Moos2, Christian Müller3

  • 1Division of Internal Medicine, Krankenhaus Maria Hilf, Daun, Germany.

The Lancet. Infectious Diseases
|February 10, 2016
PubMed

Insights

Recent advances enhance understanding of Tropheryma whipplei infection and Whipple's disease. New research clarifies pathogenesis and treatment strategies for this rare bacterial disorder.

Area of Science:

  • Medical microbiology
  • Epidemiology
  • Cellular biology

Background:

  • Whipple's disease is a rare bacterial infection caused by Tropheryma whipplei.
  • Historically, understanding its clinical spectrum and natural history has been limited.

Purpose of the Study:

  • To summarize current knowledge and recent findings on Tropheryma whipplei infection.
  • To highlight advancements in understanding Whipple's disease.

Main Methods:

  • Review of recent advances in microbiology, epidemiology, and cellular biology.
  • Integration of data from expanded diagnostic methods (histopathology, immunohistochemistry, PCR, bacterial culture).
  • Analysis of interdisciplinary and transnational research on pathogenesis and treatment.

Main Results:

  • Improved understanding of the clinical range and natural course of Tropheryma whipplei infection.
  • Clarification of Whipple's disease pathogenesis through collaborative research.
  • Enabling of controlled trials for evaluating different treatment strategies.

Conclusions:

  • Current knowledge on Tropheryma whipplei infection and Whipple's disease has significantly advanced.
  • Interdisciplinary research has been crucial for understanding pathogenesis and guiding treatment.
  • Expanded diagnostic tools have improved the identification and management of Whipple's disease.

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