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Related Experiment Video

Updated: Mar 26, 2026

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An Avid Imitator.

Dimitrios Farmakiotis1, Alexis Liakos2, Michael B Miller3

  • 1Division of Infectious Diseases, Brigham and Women's Hospital and Dana-Farber Cancer Institute Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Journal of Clinical Medicine Research
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PubMed
Summary
This summary is machine-generated.

Disseminated cryptococcal disease can mimic lymphoma in patients with hematologic malignancies. Testing for cryptococcal antigen is crucial for diagnosing this opportunistic infection in patients with unexplained symptoms.

Keywords:
CryptococcusLymphomaOpportunistic infections

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Area of Science:

  • Infectious Diseases
  • Hematology
  • Oncology

Background:

  • Patients with hematologic malignancies undergoing chemotherapy are at increased risk for opportunistic infections.
  • Disseminated fungal infections can present with nonspecific symptoms, complicating diagnosis.

Observation:

  • A case of disseminated cryptococcal disease is presented, which coexisted with and mimicked lymphoma.
  • The patient presented with symptoms suggestive of lymphoma, including lymphadenopathy and pulmonary findings.

Findings:

  • Serum cryptococcal antigen testing is a valuable diagnostic tool.
  • This test should be considered in lymphopenic patients with hematologic malignancies presenting with unexplained fever, lymphadenopathy, or pulmonary findings.

Implications:

  • Early diagnosis of opportunistic infections like cryptococcosis is vital for guiding appropriate management in immunocompromised patients.
  • Distinguishing between opportunistic infections and disease progression (e.g., lymphoma) is critical for effective treatment strategies.