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Related Experiment Video

Updated: May 26, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

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Invasive Fusariosis: A Retrospective Case Series Evaluating In Vitro Minimum Inhibitory Concentrations and Clinical

Victor Kovac1,2,3,4, Sarah P Hammond2,4,5, Nicolas C Issa1,2,3

  • 1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Open Forum Infectious Diseases
|May 25, 2026
PubMed
Summary

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This summary is machine-generated.

Invasive fusariosis (IF) is a serious fungal infection in immunocompromised patients. Despite high antifungal drug resistance, combination therapy with triazoles and terbinafine shows promising clinical responses and survival.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Invasive fusariosis (IF) is a rare, aggressive fungal infection primarily affecting immunocompromised individuals.
  • Optimal treatment for IF remains challenging due to elevated antifungal drug minimum inhibitory concentrations (MICs).

Purpose of the Study:

  • To analyze patient characteristics, treatment strategies, and outcomes for invasive fusariosis.
  • To evaluate the efficacy of antifungal therapies in patients with IF, considering organism susceptibility.

Main Methods:

  • Retrospective analysis of 21 proven or probable IF cases (January 2015 - April 2024).
  • Collection of data on patient demographics, clinical presentation, antifungal susceptibility testing, therapeutic regimens, and 12-week outcomes.
Keywords:
Fusariumhematologic malignancyisavuconazoleposaconazoleterbinafinevoriconazole

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  • Identification of causative *Fusarium* species.

    • Main Results:

    • The study included 21 patients (mean age 60 years, 71% male), predominantly with hematologic disorders (71%) and neutropenia (73%).
    • *Fusarium solani* complex was the most common species (38%). High MICs were observed for triazoles (94%) and terbinafine (65%).
    • Combination therapy (triazole + terbinafine) was used in 62% of patients, with a 76% 12-week survival rate and 57% complete response.

    Conclusions:

    • Invasive fusariosis carries a high mortality rate, particularly in patients with hematologic malignancies.
    • Despite elevated MICs, combination antifungal therapy including triazoles and terbinafine demonstrates clinical efficacy and improves survival in IF.
    • Early diagnosis, species identification, susceptibility testing, and aggressive management including surgical debridement are crucial for improving outcomes.