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Related Experiment Video

Updated: Mar 26, 2026

Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
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Active C4 Electrodes for Local Field Potential Recording Applications.

Lu Wang1, David Freedman2, Mesut Sahin3

  • 1Department of Electrical and Computer Engineering, Boston University, 8 Saint Mary's St, Boston 02215, MA, USA. wanglu@bu.edu.

Sensors (Basel, Switzerland)
|February 11, 2016
PubMed
Summary

This study presents a novel neural recording integrated circuit (IC) chip that seamlessly integrates active circuits with electrodes using IBM C4 bumps. This scalable design offers a cost-effective solution for high-density neural recording arrays.

Keywords:
3D electrodesC4CMOSMEAextracellularin vitroin vivoneural sensors

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Area of Science:

  • Neuroscience
  • Electrical Engineering
  • Biomedical Engineering

Background:

  • Extracellular neural recording with multi-electrode arrays (MEAs) is crucial for network-level neural function studies.
  • Integrating active circuits with high-density MEAs is often costly and time-consuming.

Purpose of the Study:

  • To develop a cost-effective and scalable neural recording integrated circuit (IC) chip.
  • To enable seamless integration of active circuitry with electrodes for high-density neural recording.

Main Methods:

  • Designed and fabricated a 4 mm × 4 mm neural recording IC chip using a 0.13 μm BiCMOS process.
  • Utilized IBM C4 bumps for direct integration of electrodes with the active chip.
  • Performed electrical testing and acute in vivo recordings in rat barrel cortex.

Main Results:

  • Achieved an input-referred noise of 4.6 μV rms (10 Hz to 10 kHz).
  • Demonstrated low power dissipation of 11.25 mW at 2.5 V (43.9 μW per channel).
  • Validated functionality through electrical tests and in vivo recordings.

Conclusions:

  • The developed IC chip offers a scalable and integrated solution for neural recording.
  • This technology facilitates high-density electrode array implementation for both in vitro and in vivo applications.
  • The seamless integration approach reduces cost and complexity in neural recording system development.