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Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research
Paul W Denton1,2,3, Ole S Søgaard4,5, Martin Tolstrup6,7
1Institute of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark. pade@clin.au.dk.
Journal of Translational Medicine
|February 11, 2016
Summary
Understanding HIV persistence during antiretroviral therapy involves temporal, spatial, and combinatorial challenges. Animal models are crucial for addressing these hurdles to achieve HIV eradication.
Area of Science:
- Virology
- Immunology
- Pharmacology
Background:
- HIV persistence, the ability of the virus to remain dormant during antiretroviral therapy (ART), presents a major obstacle to complete HIV eradication.
- Understanding the temporal, spatial, and combinatorial factors influencing HIV persistence is critical for developing effective treatment strategies.
Purpose of the Study:
- To provide a comprehensive review of translational research advances in animal models for studying HIV persistence.
- To highlight how animal models address key challenges in HIV persistence research.
Main Methods:
- Review of recent studies utilizing humanized mice and non-human primate models of HIV.
- Analysis of research addressing temporal, spatial, and combinatorial challenges in HIV persistence.
Main Results:
- Animal models offer controlled experimental conditions to investigate the establishment and maintenance of HIV persistence.
- These models facilitate direct testing of therapeutic strategies aimed at eradicating persistent HIV.
Conclusions:
- Advances in animal models are crucial for overcoming research challenges in HIV persistence.
- Continued research in these models will accelerate progress towards achieving a functional cure for HIV.
