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Assessment of Growth of Infants Fed an Amino Acid-Based Formula

Mark Corkins1, Laura A Czerkies2, Heidi M Storm2

  • 1Division Chief, Division of Pediatric Gastroenterology, Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, TN, USA.; Professor, Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA.

Clinical Medicine Insights. Pediatrics
|February 11, 2016
PubMed

Insights

New amino acid-based formula (AAF) supports infant growth comparably to existing options. This study found no significant differences in daily weight gain for infants fed the test AAF versus a control AAF.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Infant Nutrition

Background:

  • Amino acid-based formulas (AAFs) are crucial for infants with specific dietary needs.
  • Evaluating the efficacy of novel AAFs is essential for improving infant health outcomes.

Purpose of the Study:

  • To compare the daily weight gain of healthy infants fed a new AAF (Test) against a commercially available AAF (Control).

Main Methods:

  • Randomized controlled trial involving healthy infants from 14 to 112 days of age.
  • Anthropometric measurements and tolerance assessments were conducted throughout the study.
  • Biochemical markers (serum albumin, plasma amino acids) were analyzed in a subset of participants.

Main Results:

  • No statistically significant difference in mean daily weight gain between the Test (27.42 ± 6.37 g/day) and Control (27.26 ± 4.92 g/day) groups (P = 0.8812).
  • Comparable formula intake, adverse events, and tolerance profiles were observed in both groups.
  • Serum albumin and plasma amino acid levels remained within normal physiological ranges for all infants.

Conclusions:

  • The new amino acid-based formula (AAF) demonstrates comparable efficacy to a commercially available AAF in supporting infant growth.
  • The findings support the use of the new AAF as a viable alternative for infant feeding.
Abstract

Keywords:
amino acid-based formulagrowthinfant formula

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