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Related Concept Videos

Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

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As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
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The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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The Nucleus01:32

The Nucleus

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
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The Nucleus01:25

The Nucleus

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
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Related Experiment Video

Updated: Mar 26, 2026

Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules
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Sister Mary Joseph nodule.

Zhaowei Zhou1, Da Zhang2

  • 1Department of Surgery Royal Blackburn Hospital Blackburn UK.

Clinical Case Reports
|February 11, 2016
PubMed
Summary

Sister Mary Joseph nodules are rare umbilical tumors indicating advanced abdominal cancer. These specific umbilical neoplasms often signal a poor prognosis for patients with intra-abdominal malignancies.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Umbilical tumors are uncommon findings in clinical practice.
  • These neoplasms can be either benign or malignant.
  • The Sister Mary Joseph nodule specifically refers to an umbilical manifestation of intra-abdominal cancer.

Purpose of the Study:

  • To define the clinical significance of Sister Mary Joseph nodules.
  • To highlight the association between umbilical neoplasms and advanced intra-abdominal malignancy.
  • To discuss the prognostic implications of this specific clinical sign.

Main Methods:

  • Literature review on umbilical neoplasms.
  • Analysis of case studies involving Sister Mary Joseph nodules.
  • Review of diagnostic criteria and prognostic factors.
Keywords:
Sister Mary Joseph noduleperitoneal carcinomatosisumbilical tumors

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CT-guided Preoperative Localization of Pulmonary Nodules Using a Glucose Test and Tissue Adhesive
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Main Results:

  • Sister Mary Joseph nodules are indicative of metastatic disease.
  • The presence of a Sister Mary Joseph nodule is frequently linked to intra-abdominal cancers.
  • These nodules are often associated with advanced stages of malignancy.

Conclusions:

  • Sister Mary Joseph nodules are a critical clinical sign of advanced intra-abdominal malignancy.
  • Diagnosis of a Sister Mary Joseph nodule warrants thorough investigation for underlying cancer.
  • The prognosis associated with Sister Mary Joseph nodules is generally poor, reflecting the advanced nature of the malignancy.