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Structural convergence during protein evolution.

F R Salemme, M D Miller, S R Jordan

    Proceedings of the National Academy of Sciences of the United States of America
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Protein structures can be similar even with different sequences, suggesting divergent evolution. However, the genetic code generally does not conserve amino acid structure during mutations, impacting evolutionary pathways.

    Area of Science:

    • Biochemistry and Molecular Biology
    • Evolutionary Biology
    • Structural Bioinformatics

    Background:

    • Recent protein crystallographic studies reveal significant tertiary structural similarities among proteins with divergent amino acid sequences and functions.
    • These structural similarities raise questions about the evolutionary origins of proteins, particularly the role of divergent evolution from a common ancestor.

    Purpose of the Study:

    • To investigate the potential for divergent evolution by analyzing the relationship between the genetic code and amino acid structural properties.
    • To assess the structural conservatism of the genetic code concerning single base substitutions and their impact on amino acid changes.

    Main Methods:

    • Graphical analysis correlating allowed single base substitutions in the genetic code with changes in encoded amino acid structural properties.

    Related Experiment Videos

  • Evaluation of codon synonymy and single-base changes leading to amino acid substitutions.

    • Main Results:

    • Significant structural conservation is observed due to codon synonymy, where different codons code for amino acids with similar structures.
    • However, the genetic code generally exhibits limited structural conservatism when single base changes result in amino acid substitutions.

    Conclusions:

    • While some structural conservation exists, the genetic code's limited conservatism in amino acid substitutions may influence protein evolution.
    • The findings provide insights into how protein structural evolution might proceed despite the inherent properties of the genetic code.