Related Experiment Video

Updated: Mar 26, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

9.2K

Defining the prognosis of chronic total occlusions during primary percutaneous coronary intervention

Ömer Şen1, Fatih Şen, Mustafa Topuz

  • 1aDepartment of Cardiology, Adana Numune Training and Research Hospital, Adana bDepartment of Cardiology, Turkey Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.

Coronary Artery Disease
|February 11, 2016
PubMed

Insights

Collateral circulation between chronic total occlusion and infarct-related artery in STEMI patients negatively impacts outcomes. These CTO-IRA collaterals are independent predictors of higher 30-day mortality.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Biology

Background:

  • The role of collateral circulation between chronic total occlusion (CTO) and infarct-related artery (IRA) in acute ST-segment elevation myocardial infarction (STEMI) is not well understood.
  • Investigating this relationship is crucial for understanding early clinical outcomes in STEMI patients.

Purpose of the Study:

  • To determine the impact of collateral circulation between CTO and IRA on early clinical outcomes in patients with acute STEMI.
  • To assess the association between CTO-IRA collaterals and procedural success, infarct size, and mortality.

Main Methods:

  • A prospective study included 1488 acute STEMI patients undergoing primary percutaneous coronary intervention.
  • Patients were categorized into three groups: CTO-IRA-related (CIR, n=56), CTO-IRA-unrelated (CIUR, n=104), and non-CTO (n=1328).
  • Comparison of clinical outcomes, procedural success, and mortality rates among the groups.

Main Results:

  • The CIR group showed higher Killip class, lower postprocedural flow, and poorer myocardial perfusion compared to CIUR and non-CTO groups.
  • The CIR group experienced significantly higher in-hospital and 30-day mortality rates.
  • CTO-IRA collaterals were identified as an independent predictor of 30-day mortality (OR=15.96).

Conclusions:

  • Coexisting CTO supplied by IRA collaterals adversely affects procedural success, infarct size, and hemodynamic conditions in STEMI patients.
  • These specific collaterals are significant independent predictors of 30-day mortality.
  • The CIUR group did not independently predict early clinical outcomes.
Abstract

More Related Videos

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

15.8K
Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion13:18

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Published on: November 22, 2024

2.3K

Related Concept Videos

Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
439
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
545
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
561