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Related Experiment Video

Updated: Mar 26, 2026

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Use of Trowell-Type Organ Culture to Study Regulation of Dental Stem Cells

Published on: July 8, 2021

Expression of Sox genes in tooth development.

Katsushige Kawasaki¹, Maiko Kawasaki, Momoko Watanabe

¹Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

The International Journal of Developmental Biology

|February 12, 2016

Summary

This summary is machine-generated.

Sox genes are crucial for organ development. This study reveals dynamic Sox gene expression patterns during mouse tooth development, highlighting their roles in specific tooth structures.

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Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Published on: May 10, 2019

Area of Science:

Developmental Biology
Genetics
Oral Biology

Background:

The Sox (SRY-box containing) gene family is vital for numerous biological processes, including organogenesis.
Understanding gene expression during tooth development is key to comprehending craniofacial development and potential anomalies.

Purpose of the Study:

To investigate the spatio-temporal expression patterns of seventeen Sox genes during murine odontogenesis.
To identify specific Sox genes involved in different stages and cell types of tooth development.

Main Methods:

Comparative in situ hybridization was employed to analyze the expression of Sox1-14, Sox17, Sox18, and Sox21 during murine tooth development.
Expression analysis spanned from the epithelial thickening to the cytodifferentiation stages of odontogenesis.

Main Results:

Localized expression of Sox6, Sox9, Sox13, Sox14, and Sox21 was detected in the tooth bud epithelium.
Sox13 exhibited restricted expression within the primary enamel knots.
At the early bell stage, Sox8, Sox11, Sox17, and Sox21 were expressed in pre-ameloblasts, while Sox5 and Sox18 were found in odontoblasts.

Conclusions:

Sox genes display dynamic and specific spatio-temporal expression during tooth development.
These findings suggest diverse roles for Sox genes in regulating cellular differentiation and patterning within the developing tooth.
The study provides a foundational expression map of Sox genes in odontogenesis, aiding future research into tooth formation and disorders.