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Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

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Related Experiment Video

Updated: Mar 26, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

Ictal motor sequences: Lateralization and localization values.

Ahmad Marashly¹, Amr Ewida², Rajkumar Agarwal³

¹Department of Child Neurology, Children's Hospital of Wisconsin/Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.

|February 12, 2016

Summary

This summary is machine-generated.

Reliable ictal motor signs in focal epilepsy help lateralize the epileptogenic zone (EZ). However, these specific motor sequences do not pinpoint the exact EZ location, which is crucial for epilepsy surgery planning.

Keywords:

Epileptogenic zone Focal epilepsy Lateralization Semiology

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Area of Science:

Neurology
Epileptology
Clinical Neuroscience

Background:

Focal epilepsy can progress to generalized motor seizures.
Accurate localization of the epileptogenic zone (EZ) is critical for successful epilepsy surgery.
Ictal motor sequences are potential biomarkers for EZ lateralization and localization.

Purpose of the Study:

To evaluate the lateralization and localization values of specific ictal motor sequences in focal epilepsy.
To identify reliable motor signs that predict the side of the EZ.
To determine if motor sequences can differentiate between temporal and extratemporal epilepsy.

Main Methods:

Retrospective analysis of ictal motor sequences in 47 focal epilepsy seizures.
Assessment of motor signs including version, tonic/clonic posturing, M2e, and Todd's paralysis.
Calculation of prevalence and positive predictive value (PPV) for lateralization and localization.

Main Results:

Version, unilateral tonic posturing, M2e, unilateral clonic seizure, asymmetric clonic ending, and Todd's paralysis were reliable lateralizing signs (PPV > 80%).
Accurate EZ lateralization (100% PPV) was achieved with two or more reliable motor signs.
Motor sequences did not differentiate between temporal and extratemporal epilepsy.

Conclusions:

Reliable ictal motor signs are highly valuable for lateralizing the EZ in focal epilepsy.
These motor signs do not provide precise localization of the EZ.
This information is particularly important for guiding epilepsy surgery decisions.