Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue
Benjamin W Lee1,2, Bohao Liu1,2, Adam Pluchinsky1
1Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Advanced Healthcare Materials
|February 12, 2016
Abstract:
This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.
