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Relation of Plasma Fibrinogen Level With the Presence, Severity, and Complexity of Coronary Artery Disease

Mehmet Mustafa Tabakcı1, Fethullah Gerin2, Murat Sunbul3

  • 11 Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|February 12, 2016
PubMed

Insights

Plasma fibrinogen, a marker of inflammation, is strongly linked to the severity and complexity of coronary artery disease (CAD). Higher fibrinogen levels predict more complex coronary artery disease in patients with stable angina.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • The relationship between plasma fibrinogen levels and the extent, severity, and complexity of coronary artery disease (CAD) in patients with stable angina pectoris (SAP) remains under-investigated.
  • Assessing this relationship is crucial for understanding disease progression and potential therapeutic targets.

Purpose of the Study:

  • To evaluate the association between plasma fibrinogen levels and coronary complexity, severity, and extent.
  • To determine if plasma fibrinogen can serve as a predictor for high SYNTAX scores (SS) in patients with stable angina.

Main Methods:

  • 134 consecutive patients with SAP undergoing coronary angiography were enrolled.
  • Baseline plasma fibrinogen levels were measured, and the SYNTAX score (SS) was calculated for each patient.
  • Patients were stratified into three groups based on SS tertiles: control (SS=0), intermediate (SS<22), and high (SS≥22).

Main Results:

  • Plasma fibrinogen levels showed a significant stepwise increase from the control group to the high SS group.
  • A strong positive correlation was observed between plasma fibrinogen levels and SS (r=0.535, P<.001).
  • Plasma fibrinogen was identified as an independent predictor of high SS (OR 1.01, P<.001), with a threshold of 411 mg/dL demonstrating 75% sensitivity and 64% specificity for predicting high SS.

Conclusions:

  • Plasma fibrinogen is a readily measurable systemic inflammatory marker.
  • Plasma fibrinogen levels are independently associated with coronary artery disease severity and complexity in patients with stable angina.
  • These findings suggest plasma fibrinogen's potential utility in risk stratification for patients with CAD.
Abstract

Keywords:
angina pectoriscoronaryfibrinogensyntax score

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