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Growing human B-cell precursors in vitro: the continuing challenge
Immunology Today
|September 1, 1989
Abstract:
Methods for propagating murine B-cell precursors in vitro have been instrumental in unraveling the cells and molecules regulating murine B-cell ontogeny. However, similar methods are not available for studying human B-cell ontogeny. Here, Tucker LeBien discusses why efforts to grow human B-cell precursors in vitro have been largely unsuccessful and proposes alternative strategies that may prove useful.
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01:21Cell Culture
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01:17Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...