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Visualizing Actin and Microtubule Coupling Dynamics In Vitro by Total Internal Reflection Fluorescence TIRF Microscopy
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Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking

Christopher Arnette1, Keyada Frye1, Irina Kaverina1

  • 1Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

Plos One
|February 12, 2016
PubMed
Summary

Proto-oncogene c-Src localization is regulated by both microtubules and actin polymerization. GEF-H1 acts as a molecular switch, coordinating c-Src vesicle trafficking for proper signaling.

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