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Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
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Practical Approaches for Detecting Selection in Microbial Genomes.

Jessica Hedge1, Daniel J Wilson1,2

  • 1Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

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|February 12, 2016
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Summary
This summary is machine-generated.

This tutorial explains how to measure microbial selection pressures using whole-genome sequencing data. It helps researchers understand pathogen evolution, virulence, and antibiotic resistance.

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Area of Science:

  • Microbial genetics and evolutionary biology.

Background:

  • Microbial genome evolution is influenced by selective pressures.
  • Understanding these pressures is crucial for addressing challenges like pathogen virulence and antibiotic resistance.

Purpose of the Study:

  • To guide researchers in applying popular methods for measuring selection in microbial pathogens.
  • To facilitate large-scale analyses of selection using whole-genome sequencing data, even within individual hosts.

Main Methods:

  • The tutorial focuses on fundamental principles of selection measurement methods.
  • It is designed to be applicable to various organisms and transferable across different research settings.

Main Results:

  • Provides practical exercises suitable for researchers with diverse programming backgrounds.
  • Enables the analysis of selection in novel contexts, such as within-host pathogen evolution.

Conclusions:

  • Empowers microbiologists to analyze microbial selection pressures effectively.
  • Enhances understanding of microbial evolution, virulence, and antibiotic resistance through accessible methods.