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Mania following ketamine abuse.

Yuan-Yuan Lu1, Chieh-Hsin Lin2, Hsien-Yuan Lane3

  • 1Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan.

Neuropsychiatric Disease and Treatment
|February 13, 2016
PubMed
Summary

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Recreational ketamine abuse, particularly through inhalation, may induce manic-like symptoms. This case highlights a potential link between long-term ketamine use and the development of mania.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor with established clinical applications.
  • However, the increasing prevalence of ketamine abuse and its adverse psychological effects are a growing concern.
  • Previous reports have noted mania induction with intravenous ketamine therapy.

Observation:

  • A case study of a 26-year-old male is presented.
  • The individual reported 12 months of ketamine abuse via inhalation.
  • Manic-like symptoms emerged following ketamine use.

Findings:

  • The case suggests a potential association between chronic ketamine abuse and the manifestation of manic symptoms.
  • This report may represent the first documented instance of mania following recreational ketamine use.
Keywords:
antidepressantbipolarketaminemania

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Implications:

  • This case underscores the potential psychiatric risks associated with recreational ketamine use.
  • Further research is warranted to explore the neurobiological mechanisms linking ketamine and mania.
  • Clinicians should be aware of the possibility of ketamine-induced mood disturbances in individuals with substance use disorders.