Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

Area of Science:

• Oncology
• Immunology
• Animal Models

Background:

• Oral squamous epithelial carcinogenesis is complex.
• Immunity and inflammation significantly impact cancer initiation and progression.
• Mouse models are vital for head and neck squamous cell carcinoma (HNSCC) research.

Purpose of the Study:

• To review immunocompromised and immunocompetent mouse models for HNSCC.
• To provide a platform for understanding HNSCC tumorigenesis.
• To highlight the role of these models in HNSCC diagnosis, monitoring, and treatment.

Main Methods:

• Literature review of immunocompromised mouse models in HNSCC research.
• Literature review of immunocompetent mouse models in HNSCC research.
• Analysis of histological, molecular, and genetic changes in oral squamous epithelial tumorigenesis using mouse models.

Main Results:

• Mouse models closely mimic human oral squamous epithelial carcinogenesis.
• Two main categories of mouse models exist: immunocompromised and immunocompetent.
• These models facilitate in vivo research for HNSCC.

Conclusions:

• Both immunocompromised and immunocompetent mouse models are essential for HNSCC research.
• Understanding these models aids in comprehending the complex changes in oral tumorigenesis.
• Mouse models are instrumental in advancing HNSCC diagnosis, monitoring, and treatment strategies.