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Related Concept Videos

Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

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In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
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Radiation: Applications01:17

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The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
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Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Applications Of NMR In Biology01:25

Applications Of NMR In Biology

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Updated: Mar 25, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Radiation Metabolomics: Current Status and Future Directions.

Smrithi S Menon1, Medha Uppal1, Subeena Randhawa1

  • 1Department of Oncology, Georgetown University Medical Center , Washington, DC , USA.

Frontiers in Oncology
|February 13, 2016
PubMed
Summary

Radiation metabolomics offers new biomarkers for predicting organ toxicity after radiation exposure. This approach aids in understanding radiation

Keywords:
biomarkersionizing radiationmetabolomics

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Toxicology

Background:

  • Ionizing radiation (IR) disrupts cellular metabolism and gene expression.
  • Current biomarkers for radiation exposure lack organ-specific predictive value, especially long-term.
  • Metabolomics provides insights into physiological responses to stress.

Purpose of the Study:

  • To review the current status of radiation metabolomics.
  • To explore metabolomics applications for identifying radiation toxicity biomarkers.
  • To discuss metabolomics integration with systems biology for understanding radiation response.

Main Methods:

  • High-resolution mass spectrometry-based metabolomics.
  • Analysis of multi-metabolite profiles.
  • Review of existing literature on radiation metabolomics.

Main Results:

  • Metabolomics can identify robust biomarkers for organ and tissue toxicity from IR.
  • A multi-metabolite profile aids in predicting individual physiological status post-exposure.
  • Identified pathways can be targeted for therapeutic development.

Conclusions:

  • Radiation metabolomics is a promising tool for assessing radiation exposure effects.
  • Metabolomics can enhance understanding of radiation's molecular basis.
  • This field supports the development of radioprotective therapeutics.