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Updated: Mar 25, 2026

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
Published on: July 22, 2015
Equilibrium microphase separation in the two-leaflet model of lipid membranes
Ramon Reigada1, Alexander S Mikhailov2,3
1Departament de Química Física i Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Avinguda Diagonal 647, 08028 Barcelona, Spain.
Abstract:
Because of the coupling between local lipid composition and the thickness of the membrane, microphase separation in two-component lipid membranes can take place; such effects may underlie the formation of equilibrium nanoscale rafts. Using a kinetic description, this phenomenon is analytically and numerically investigated. The phase diagram is constructed through the stability analysis for linearized kinetic equations, and conditions for microphase separation are discussed. Simulations of the full kinetic model reveal the development of equilibrium membrane nanostructures with various morphologies from the initial uniform state.
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