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[Bone Marrow Lesion - Risk-Factors and Pathophysiological Relevance: Systematic Review].

G Spahn1, M Biehl1, G O Hofmann2

  • 1Unfallchirurgie und Orthopädie, Praxisklinik für Unfallchirurgie und Orthopädie, Eisenach.

Zeitschrift Fur Orthopadie Und Unfallchirurgie
|February 13, 2016
PubMed
Summary
This summary is machine-generated.

Bone marrow lesions (BMLs) in the knee are linked to osteoarthritis progression. Factors like female gender, age, and obesity are weakly associated, while cartilage damage and existing osteoarthritis strongly predict BML development and worsening knee conditions.

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Area of Science:

  • Orthopedics
  • Radiology
  • Rheumatology

Background:

  • Bone marrow lesions (BMLs) are increasingly recognized in knee imaging.
  • Understanding the risk factors and progression associated with BMLs is crucial for managing knee osteoarthritis.

Purpose of the Study:

  • To systematically review and meta-analyze the risks and associated factors for knee symptoms and osteoarthritis progression in idiopathic bone marrow lesions (BMLs).

Main Methods:

  • A comprehensive search of PubMed, EMBASE, Web of Science, and Cochrane databases was conducted up to October 2015.
  • Included studies focused on bone marrow edema and knee conditions.
  • Data from 30 studies were synthesized for the final evaluation.

Main Results:

  • The mean frequency of BMLs across studies was 37.2%, influenced by MRI technique (1.0-3.0T).
  • Weakly associated risk factors included female gender, increasing age, and overweight/obesity.
  • BMLs showed significant associations with cartilage lesions (OR=5.5), development of radiological osteoarthritis (OR=3.6), and osteoarthritis progression over 3 years (OR=4.4).

Conclusions:

  • BML occurrence is a significant indicator of severe degenerative knee pathologies.
  • BMLs appear to predict disease progression, though clinical relevance and treatment implications require further investigation.