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Surveillance of salmonellae in India for drug resistance
Indian Journal of Medical Sciences
|June 1, 1989
Abstract:
Out of 3001 salmonella received during 1984-85, 2985 strains were tested for antibiotic resistance and R-pattern transfer. Multidrug resistance was observed in 73% of diarrhoeal and 43% of non-diarrhoeal isolates. Antibiotic resistance markers were transferable in 46.6% of diarrhoeal and 41.1% of non-diarrhoeal isolates. Two out of 4 salmonella sero-types isolated for the first time in India during this period were multidrug resistant.
Insights
Most Salmonella strains in India showed multidrug resistance, with higher rates in diarrheal cases. Resistance genes were frequently transferable, posing a significant public health concern.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Salmonella is a significant cause of bacterial infections worldwide.
- Antibiotic resistance in bacterial pathogens is a growing global health threat.
- Understanding resistance patterns in specific regions like India is crucial.
Purpose of the Study:
- To investigate the prevalence of antibiotic resistance in Salmonella strains isolated in India.
- To determine the transferability of antibiotic resistance markers (R-pattern transfer).
- To identify multidrug-resistant Salmonella serotypes.
Main Methods:
- Antibiotic resistance testing was performed on 2985 Salmonella strains.
- R-pattern transfer experiments were conducted.
- Salmonella serotypes were identified.
Main Results:
- Multidrug resistance was observed in 73% of diarrheal and 43% of non-diarrheal isolates.
- Antibiotic resistance markers were transferable in 46.6% of diarrheal and 41.1% of non-diarrheal isolates.
- Two novel multidrug-resistant Salmonella serotypes were identified in India.
Conclusions:
- High rates of multidrug resistance and gene transferability in Salmonella strains from India.
- The findings highlight the urgent need for antimicrobial stewardship and surveillance.
- Emergence of new resistant serotypes necessitates ongoing monitoring.